Natural Killer Cell Adoptive Transfer Therapy
نویسندگان
چکیده
منابع مشابه
Characterization of the natural killer T-cell response in an adoptive transfer model of atherosclerosis.
Natural killer T (NKT) cells have recently been implicated in atherogenesis, primarily for their ability to recognize and respond to lipid antigens. Because the atherosclerotic lesion is characterized by the retention and modification of lipids in the vascular wall, NKT cells may be involved in promoting the local vascular inflammatory response. Here, we investigate the proatherogenic role of N...
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The survival of patients with metastatic or relapsed Ewing sarcoma (ES) remains dismal despite intensification of combination chemotherapy and radiotherapy, precipitating the need for novel alternative therapies with minimal side effects. Natural killer (NK) cells are promising additions to the field of cellular immunotherapy. Adoptive NK cell therapy has shown encouraging results in hematologi...
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Melanoma is the most aggressive skin cancer and its incidence is gradually increasing worldwide. Patients with metastatic melanoma have a very poor prognosis (estimated 5-year survival rate of <16%). In the last few years, several drugs have been approved for malignant melanoma, such as tyrosine kinase inhibitors and immune checkpoint blockades. Although new therapeutic agents have improved pro...
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It has been documented that immunosurveillance plays an important role in cancer development in both human and animals [1,2]. Cancer immunosurveillance is the function of immune system in recognizing and reacting against aberrant cancer cells in the body. Thus, the interactions between cancer cells and immune cells play a pivotal role in cancer development. In cancer patients, however, tumors g...
متن کاملAdoptive transfer of TRAIL-expressing natural killer cells prevents recurrence of hepatocellular carcinoma after partial hepatectomy.
BACKGROUND Antitumor activity of the liver natural killer (NK) cells reportedly decreases after partial hepatectomy, suggesting that patients with such depressed immune status are susceptible to the recurrence of hepatocellular carcinoma (HCC). We hypothesize that adoptive immunotherapy using activated NK cells can be a novel strategy to improve the depressed immune status in patients with HCC ...
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ژورنال
عنوان ژورنال: The Cancer Journal
سال: 2015
ISSN: 1528-9117
DOI: 10.1097/ppo.0000000000000156